CORROSION AND PROTECTION    Vol (52) Issue: 01 2024:
RESEARCH ARTICLE Current Issue | Archive |
SYNTHETIC UTILITY OF N-CHLORONIPECOTAMIDE IN THE KINETIC STUDY OF OXIDATION OF ISATIN IN AQUEOUS ACETONITRILE MEDIUM BY POTENTIOMETRIC METHOD


Dr. V. Priya1, Dr. M. Subalakshmi*, Dr. V. Priya Roseline1, S.M. Bavaani2 and J. Dawincy Nisha2
  • Abstract
  • Kinetic study is an expanding field of reach in chemistry. N-halo compounds are versatile reagents and have been employed as potentially reactive intermediates that are widely used in organic synthesis. Halogens, N-haloamides and imides are the versatile agents used for the oxidation of a wide variety of organic compounds. Hence, a halogen except fluorine, when linked with nitrogen acquire a positive charge. Isatin, also known as tribulin, is an organic compound derivative of indole. Isatin is a known natural product which can be found in plants of the genus isatis, in couroupitaguianensis and also in humans, as a metabolic derivative of adrenaline. The synthetic versatility of isatin has led to the extensive use of this compound in organic synthesis. It act as a precursor for the synthesis of other heterocyclic compounds. Isatins, associated with amino heterocyclics have been used as pigments and dyes, since they are well-known colour reagents for amino acids. It is usually employed as building block for the synthesis of a wide variety of biologically active compounds including antitumorals, antivirals, anti HIVs and antituberculars. In the present study, oxidation of isatin has been carried out by N-Chloronipecotinamide (NCNP) in aqueous acetonitrile medium. The rate of the reaction shows first order dependence on [NCNP], [HClO4], [NaCl] and fractional order dependence on [substrate]. The rate increases with the decrease in dielectric constant of the medium. The addition of the reaction product, nipecotinamide has a less significant effect on the reaction rate. From the plot of log k vs 1/T, the Arrhenius and thermodynamic activation parameters have been calculated.
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